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In vivo, in U87MG glioma-bearing mice, CTX nanoparticles (10 mg/kg) showed a tumor-to-normal brain fluorescence ratio of 4.2 0.7 versus 1.3 0.2 for non-targeted nanoparticles, reduced tumor volume by 63% over 21 days, and extended median survival by 1.8-fold

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Commonly reported adverse effects include: Injection site reactions (redness, pain, swelling) Fluid retention (peripheral oedema, joint pain, or carpal tunnel syndrome) related to GH-mediated effects Glucose metabolism changes : tesamorelin can raise blood glucose levels and may worsen insulin resistance

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